Does polymicrogyria affect life expectancy?
The quality of life and life expectancy for people with BPP are not well-described but may depend on severity of symptoms, whether complications develop, and whether other birth defects or an underlying syndrome are present.
Can polymicrogyria be cured?
The Polymicrogyria (PMG) malformation cannot be reversed, but the symptoms may be treated in children and adults. The first-line treatment for persons with seizures is anti-seizure medications, and the medication chosen depends on the type of seizures or epilepsy syndrome.
Is polymicrogyria a genetic condition?
Polymicrogyria can result from both genetic and environmental causes. It may occur as an isolated finding or as part of a syndrome . Treatment is based on the signs and symptoms present in each person.
What causes bilateral Perisylvian polymicrogyria PMG?
Genetic causes may include a contiguous gene disorder (a disorder caused by the deletion of multiple adjacent genes ) or a single gene disorder (a disorder caused by a mutation in one gene). BPP may also have non-genetic causes.
What is unilateral polymicrogyria?
Unilateral polymicrogyria is a cerebral cortical malformation characterized by unilateral excessive cortical folding and abnormal cortical layering. It comprises two sub-types depending on the areas affected: unilateral hemispheric and focal polymicrogyria (see these terms).
When does polymicrogyria develop?
The age of seizure onset has been found to occur anywhere from 20 months to 15 years, and in most cases the seizures were intractable (meaning hard to control).
How common is bilateral polymicrogyria?
The prevalence of isolated polymicrogyria is unknown. Researchers believe that it may be relatively common overall, although the individual forms of the disorder (such as bilateral generalized polymicrogyria) are probably rare.
What is bilateral polymicrogyria?
Bilateral perisylvian polymicrogyria (BPP) is a rare neurological disorder that affects the cerebral cortex (the outer surface of the brain). BPP is a subtype of a broader condition known as polymicrogyria. The cerebral cortex of the brain normally consists of several deep folds and grooves.
What is dysplasia in the brain?
What is Cortical Dysplasia? Cortical dysplasia occurs before a child is born, when developing brain cells, or neurons, fail to reach the parts of the brain for which they are genetically destined. As a result, those areas of the brain lack the appropriate neural connections to function properly.
What is bilateral Polymicrogyria?
What is bilateral syndrome?
Specialty. Neurology. Congenital bilateral perisylvian syndrome (CBPS) is a rare neurological disease characterized by paralysis of certain facial muscles and epileptic seizures.
What do you need to know about polymicrogyria?
Summary Summary. Polymicrogyria is a condition characterized by abnormal development of the brain before birth. Specifically, the surface of the brain develops too many folds which are unusually small.
How is polymicrogyria diagnosed in the cerebral cortex?
The diagnosis of polymicrogyria is made by imaging brain structures using MRI. Typical findings include areas of the cerebral cortex with a complex set of small gyri that appear fused to each other and separated by shallow sulci. These findings may be isolated to one side of the brain (unilateral) or may involve both sides of the brain (bilateral).
Is there such a thing as bilateral perisylvian polymicrogyria?
Bilateral perisylvian polymicrogyria also called congenital bilateral perisylvian syndrome, is a rare neurological disorder that affects the cerebral cortex (the outer surface of the brain) 6). Bilateral perisylvian polymicrogyria is a subtype of a broader condition known as polymicrogyria.
How is polymicrogyria related to grey matter heterotopias?
Polymicrogyria is one of many malformations of cortical development (see classification system for cortical malformations ), and along with grey matter heterotopias, falls under a bewildering group of conditions characterized by abnormalities both in the migration of neurons to the cortex and abnormal cortical organization.