How does metolazone work with furosemide?

Even at low doses metolazone significantly potentiates the diuretic effects of furosemide and therefore simplifies the treatment of fluid retention. High doses of furosemide can be avoided in many cases, a factor of particular advantage in ambulatory long term therapy and in patients with decreased kidney function.

What is the difference between metolazone and Lasix?

Lasix (furosemide) and Zaroxolyn (metolazone) are diuretics (water pills) used treat excess accumulation of fluid or swelling of the body (edema) and high blood pressure (hypertension). Lasix is a brand name for furosemide. Zaroxolyn is a brand name for metolazone.

When do you add metolazone to Lasix?

For patients who respond poorly to large dosages of loop diuretics, consider adding 5 to 10 mg of metolazone (Zaroxolyn) one hour before the dose of furosemide once or twice a week as tolerated.

Can you take metolazone and Lasix together?

You may need dose adjustments or special tests in order to safely take both medications together. This combination may lower levels of certain minerals in your body such as potassium, magnesium, and sodium.

Is metolazone contraindicated in renal failure?

Metolazone should be used cautiously in patients with severe renal disease including severe renal impairment or renal failure. Hypovolemia can precipitate azotemia in these patients. Therapy should be interrupted or discontinued if renal impairment or azotemia worsens.

Can you take Metolazone and furosemide together?

Before taking furosemide, tell your doctor if you also use metOLazone. You may need dose adjustments or special tests in order to safely take both medications together. This combination may lower levels of certain minerals in your body such as potassium, magnesium, and sodium.

Can you take Lasix and carvedilol together?

Using furosemide and carvedilol together may lower your blood pressure and slow your heart rate. This can cause dizziness, or feeling like you might pass out, weakness, fainting, fast or irregular heartbeats, or loss of blood glucose control.

Can you give metolazone with Lasix?

Can I take metolazone and Lasix together?

Is metolazone a loop diuretic?

Alternatively, metolazone administered with a loop diuretic can be uniquely successful in effecting a diuresis in edematous or diuretic-resistant patients. Furosemide has been the loop diuretic most commonly administered with metolazone in clinical practice.

What is the mechanism of action of metolazone?

Go to: Mechanism of Action Metolazone works by inhibiting sodium transport across the epithelium of the renal tubules (mostly in the distal tubules), resulting in a decrease in sodium reabsorption and an increase in sodium, chloride, and water excretion.

When to take metolazone before or after furosemide?

In patients resistant to loop diuretics, metolazone should be given one hour before the regular morning dose of furosemide. Adverse Effects Hyperuricemia is a common adverse effect and is due to competitive inhibition of uric acid secretion and a decrease in extracellular fluid from diuretic effects.

How is metolazone similar to thiazide diuretics?

 While metolazone is similar to thiazide diuretics in its mechanism of action, it does differ in its use in patients with impaired renal function. Thiazide diuretics decrease glomerular filtration rate (GFR) and are therefore less effective in patients with renal impairment.

Can a kidney injury be caused by metolazone?

Because metolazone exerts its main effect in the distal tubule of the nephron, a change in renal function can be expected and lead to occasional instances of acute kidney injury.   The likelihood of these events has not been established, and metolazone may be the only option indicated with reduced renal function.