How often should I increase my hydroxyurea dosage?

-Counts in acceptable range: Increase dose 5 mg/kg/day every 12 weeks to a maximum dose of 35 mg/kg/day (maximal dose is the highest dose that does not produce toxic blood counts over 24 consecutive weeks); increase dosing only if blood counts are in acceptable range; do not increase if myelosuppression occurs.

When to start Hu in patients with hyperleukocytosis?

Patients with AML and hyperleukocytosis (WBC count >50 x 10 9 /L) were immediately started on HU (50 mg/kg/day orally x 4 days), regardless of hospital bed availability. Response was evaluated after 4 days of HU; patients were considered responders if >50% reduction of the initial WBC count was observed.

How often should I take droxia hydroxyurea titrate?

Start: 15 mg/kg/day as single dose; monitor patient’s blood count every two weeks. Titrate by 5 mg/kg/day q12wk. Dose is not increased if blood counts are between acceptable range and toxic. Not to exceed 35 mg/kg/day.

How is hydroxyurea used to treat acute myeloid leukemia?

Hydroxyurea in the Early Management of Acute Myeloid Leukemia and Hyperleukocytosis. Blood (2007) 110 (11): 4368.

Dosing based on blood counts: -Counts in acceptable range: Increase dose 5 mg/kg/day every 12 weeks to a maximum dose of 35 mg/kg/day (maximal dose is the highest dose that does not produce toxic blood counts over 24 consecutive weeks); increase dosing only if blood counts are in acceptable range; do not increase if myelosuppression occurs.

How many milligrams of hydroxyurea are in a capsule?

Consumer resources Hydroxyurea Hydroxyurea Capsules 500 mg Hydroxyurea Tablets Hydroxyurea Capsules 200 mg, 300 mg, 400 mg Hydroxyurea (Advanced Reading)

When to reduce hydroxyurea dosage after hematologic recovery?

-Dosing after hematologic recovery: Reduce dose by 2.5 mg/kg/day. Reduce the dose from the dose associated with hematologic toxicity. May titrate up or down every 12 weeks in 2.5 mg/kg/day increments. The patient should be at a stable dose with no hematologic toxicity for 24 weeks.

How often should I take hydroxyurea for sickle cell anemia?

Use: To reduce the frequency of painful crises and to reduce the need for blood transfusions in patients with sickle cell anemia with recurrent moderate to severe painful crises. -Reduce the dose by 5 mg/kg/day. -Reduce the dose from the dose associated with hematologic toxicity. -May titrate up or down every 8 weeks in 5 mg/kg/day increments.