What does a low IGF-1 level mean?
Decreased IGF-1 If the IGF-1 level is decreased, then it is likely that there is a GH deficiency or an insensitivity to GH. If this is in a child, the GH deficiency may have already caused short stature and delayed development and may be treated with GH supplementation.
How can I increase my IGF?
Central levels of IGF-I can be increased directly, by administering IGF-I, or indirectly by blocking the insulin-like growth factor binding proteins (IGFBPs). The IGFBP family has the unique ability to regulate IGF-I levels by sequestering IGF-I into an inactive complex.
Why is IGF bad?
The side effects of IGF-1 may be similar to those of other growth hormones. These include overgrowth of body tissues, known as acromegaly, and damage to the joints, liver, and heart. IGF-1 can cause your blood glucose levels to drop.
What should my growth hormone level be?
Normal Results The normal range for GH level is typically: For adult males — 0.4 to 10 nanograms per milliliter (ng/mL), or 18 to 44 picomoles per liter (pmol/L) For adult females — 1 to 14 ng/mL, or 44 to 616 pmol/L. For children — 10 to 50 ng/mL, or 440 to 2200 pmol/L.
What should your growth hormone level be?
What’s the difference between IGF 1 and IGFBP-3?
IGF-1 and IGFBP-3 are GH dependent, whereas IGFBP-1 is insulin regulated. IGFBP-1 production from the liver is significantly elevated during insulinopenia while serum levels of bioactive IGF-1 is increased by insulin. Studies of recent interest show that the Insulin/IGF axis play an important role in aging.
How does insulin like growth factor 1 ( IGF-1 ) work?
GH induces the generation of insulin-like growth factor 1 (IGF-1, also called somatomedin 1) in the liver and regulates the paracrine production of IGF-1 in many other tissues.7 Figure 1 The cascade of the growth hormone axis.
Where is the IGF-1 gene located on the chromosome?
THE IGF-1 GENE The IGF-1 gene is on the long arm of chromosome 12q23–23.15,16The human IGF-1 gene consists of six exons, including two leader exons, and has two promoters.17 IGF binding proteins (IGFBPs)
What is the role of IGF-1 in brain development?
IGF-1 has an involvement in regulating neural development including neurogenesis, myelination, synaptogenesis, and dendritic branching and neuroprotection after neuronal damage. Increased serum levels of IGF-I in children have been associated with higher IQ.
