What does pyrazinamide target?

Pyrazinamide kills or stops the growth of certain bacteria that cause tuberculosis (TB). It is used with other drugs to treat tuberculosis. It is a highly specific agent and is active only against Mycobacterium tuberculosis.

Who uses pyrazinamide?

This leaflet is about the use of pyrazinamide for the treatment of tuberculosis (TB for short). Your child will have to take up to four medicines for at least 3-6 months to cure their TB. This leaflet has been written for parents and carers about how to use this medicine in children.

Why is pyrazinamide stopped?

Adverse effects The most common (roughly 1%) side effect of pyrazinamide is joint pains (arthralgia), but this is not usually so severe that patients need to stop taking it. Pyrazinamide can precipitate gout flares by decreasing renal excretion of uric acid.

Can I take pyrazinamide?

Pyrazinamide comes as a tablet to take by mouth. It usually is taken once a day (at the same time each day) or in larger doses twice a week. Pyrazinamide may be taken with or without food.

What is the MOA of pyrazinamide?

The exact mechanism of action for PZA is unknown [3]. PZA and its analog, 5-chloro-PZA, may inhibit the fatty acid synthetase I (FASI) enzyme of M. tuberculosis [4,5]. PZA is generally considered to be a bacteriostatic agent.

What drug class is pyrazinamide?

Pyrazinamide is a prescription medicine used to treat the symptoms of Tuberculosis. Pyrazinamide may be used alone or with other medications. Pyrazinamide belongs to a class of drugs called Antitubercular Agents.

What drug class is ethambutol?

Ethambutol belongs to a group of drugs called antimycobacterial antibiotics. TB is caused by a certain bacteria. Ethambutol works by stopping the bacteria from forming a cell wall, which kills the bacteria. This medication comes in tablet form.

What is the brand name of pyrazinamide?

Pza-Ciba – Novartis (Sandoz) [Pyrazinamide]

What is pyrazinamide made of?

Each pyrazinamide tablet for oral administration contains 500 mg of pyrazinamide and the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, dibasic calcium phosphate (dihydrate), microcrystalline cellulose, and stearic acid.

What is another name for ethambutol?

BRAND NAME(S): Myambutol. USES: Ethambutol is used with other medications to treat tuberculosis (TB).

What are the first line drugs?

a drug that is the first choice for treating a particular condition because it is considered a very effective treatment for that condition with the least likelihood of causing side effects. A first-line medication may be a class of drugs (e.g., SSRIs for depression) as well as a single drug.

How is pyrazinamide used in the treatment of tuberculosis?

Pyrazinamide is a pyrazine that is used therapeutically as an antitubercular agent.; Target: Antibacterial; Pyrazinamide is a prodrug that stops the growth of Mycobacterium tuberculosis. MedChem Express HY-B0271

What should the concentration of pyrazinamide be?

Pyrazinoic acid or pyrazinamide at a concentration of 0.4 (about 50 mg/L) or 4 mM (500 mg/L) and dinitrophenol (DNP) at 4 mM as a control were added to the cell suspensions and the mixtures were incubated at 37°C for various time points.

Are there any side effects to taking pyrazinamide?

Pyrazinamide is a medication used to treat tuberculosis. It is not generally recommended for the treatment of latent tuberculosis. Common side effects include nausea, loss of appetite, muscle and joint pains, and rash. More serious side effects include gout, liver toxicity, and sensitivity to sunlight.

How does pyrazinamide affect the uptake of serine?

Pyrazinoic acid at 100 and 400 mg/L inhibited the uptake of serine at acid pH 5.0 (Figure 2 a), but had little effect at pH 7.0 (Figure 2 b). The inhibitory effect of pyrazinoic acid on serine transport was more pronounced at 400 mg/L than at 100 mg/L at acid pH (Figure 2 a).