What is GFAP in astrocytoma?
The glial fibrillary acidic protein (GFAP) is a classical marker of astrocytoma, both in clinical and experimental settings. GFAP is used to determine glial differentiation, which is associated with a less malignant tumor.
What is GFAP promoter?
GFAP promoter (Astrocytes) in pDRIVE expression plasmid The glial fibrillary acidic protein (GFAP) is an intermediate filament protein found almost exclusively in astrocytes. The promoter of the GFAP gene was shown to direct astrocyte-specific transcription in vitro, in vivo [1], and in transgenic mice [2].
What is positive GFAP?
In ependymal and oligodendroglial tumours a high number of positive neoplastic elements were detected, GFAP positive were also the peri-vascular cells of a so-called astroblastoma. These results demonstrate that GFAP is not a specific astrocytic, but a glial-specific protein.
What is the best treatment for astrocytoma?
Treatment
- Surgery to remove the astrocytoma. Your brain surgeon (neursurgeon) will work to remove as much of the astrocytoma as possible.
- Radiation therapy. Radiation therapy uses high-energy beams, such as X-rays or protons, to kill cancer cells.
- Chemotherapy.
- Clinical trials.
- Supportive (palliative) care.
What does GFAP stand for?
Glial fibrillary acidic protein (GFAP) is an intermediate filament, which provides mechanical support to cells.
What is GFAP used for?
GFAP is an intermediate filament protein (Eng et al., 2000) expressed primarily by astrocytes in the CNS. Its main function is to maintain astrocyte structural integrity and aid in cell movement and shape change (Eng et al., 2000).
What is GFAP antibody?
GFAP is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system.
Is pilocytic astrocytoma curable?
Pilocytic astrocytomas are low-grade gliomas, slow-growing tumors that arise from glial cells. Pilocytic astrocytoma is the most benign and most treatable of the gliomas. The cure rate is over 90 percent.
Where is GFAP found?
glial cells
Glial fibrillary acidic protein (GFAP) was first isolated in 1971 and is only found in glial cells of the CNS, constituting the major part of the cytoskeleton of astrocytes. GFAP is a biomarker for astroglial injury, as is S100β.
What kind of tumor is a pilocytic astrocytoma?
Pilocytic astrocytomas are a specific type of astrocytoma, and also belong to the broader category of gliomas – tumors that arise from glial cells. This is because astrocytes are a type of glial cell. For this reason, pilocytic astrocytomas (grade I) may also be called a “low-grade glioma.”
Is there a link between NF1 and pilocytic astrocytomas?
The association between NF1 and pilocytic astrocytomas is so strong that up to 20% of all patients with NF1 will develop these tumours, typically in early childhood. Conversely, approximately one-third of pilocytic astrocytomas involving the optic nerves have associated NF1.
How is GFAP detected in neoplastic astrocytes?
Neoplastic astrocytes share with normal ones the presence of intermediate cytoplasmic filaments . The protein of these filaments, glial fibrillary acidic protein ( GFAP ), can be detected by immunohistochemistry.
Are there side effects for children with pilocytic astrocytoma?
Children with cerebellar pilocytic astrocytoma may experience side effects related to the tumor itself depending on the location and related to the treatment. Strabismus. Symptoms related to increased pressure in the brain often disappear after surgical removal of the tumor.
