What is neurotransmitter hypothesis?
In the 1960s, the “catecholamine hypothesis” was a popular explanation for why people developed depression. This hypothesis suggested that a deficiency of the neurotransmitter norepinephrine (also known as noradrenaline) in certain areas of the brain was responsible for creating depressed mood.
When was the monoamine hypothesis discovered?
At 1970, the “monoamine hypothesis” came up, one of the first concrete hypothesis of depression 24 . It was found that the brain monoamines serotonin, dopamine, and noradrenaline are decreased in their extracellular synaptic concentrations in the depressive states of MDD. …
Is the monoamine hypothesis true?
Conclusion. It is asserted that the monoamine hypothesis, which claims that low synaptic levels of monoamines are a primary etiology of disease, is not a valid primary reference point for understanding chronic electrical dysfunction related to the centrally acting monoamines.
What is the monoamine hypothesis psychology?
the theory that depression is caused by a deficit in the production or uptake of the amine compounds serotonin, norepinephrine, and dopamine.
What evidence support the monoamine hypothesis of depression?
Another piece of evidence in support of the Monoamine Hypothesis is that levels of 5-HT, as measured by its metabolites, seem to be correlated with depression. For example, patients who have low levels of a 5-HT metabolite were found to be more likely to have committed suicide.
What is a monoamine agonist?
Monoamine agonists are the most widely used class of psychotropic drugs. There are three major monoamines, and thus three main types of monoamine agonists. Specific phenomena surveyed include SRI tolerance, sexual dysfunction, drug interactions, serotonin withdrawal syndrome, and suicide and akathisia.
Where did the monoamine hypothesis come from?
In the 1950s, the amine hypothesis of depression was proposed after it was observed that patients treated for hypertension with reserpine developed depression [1].
What are examples of monoamines?
Monoamines refer to the particular neurotransmitters dopamine, noradrenaline and serotonin. Dopamine and noradrenaline are sometimes also referred to as catecholamines.
What does the monoamine hypothesis suggest?
The monoamine hypothesis is the most common of such hypotheses of the pathophysiology of MDD. This hypothesis is quite simple and easily understandable; the concentrations of monoamines, such as serotonin, noradrenaline, and dopamine, in synaptic gaps are decreased in the depressive state.
