What is the mantle zone of a lymph node?
The mantle zone (or just mantle) of a lymphatic nodule (or lymphatic follicle) is an outer ring of small lymphocytes surrounding a germinal center. It is also known as the “corona”. It contains transient lymphocytes. It is the location of the lymphoma in mantle cell lymphoma.
What is marginal zone of lymph node?
The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.)
What is the importance of the Paracortical region of a lymph node?
Each compartment has important functions in enabling communication between lymphocytes. The outer layer (Cortex) contains the B-cell areas, or follicles. The middle layer (Paracortex) is mostly populated by T cells and dendritic cells (Figure 1).
What are marginal zone B cells?
Key Points. Marginal zone (MZ) B cells are strategically located at the interface between the circulation and the white pulp of the spleen, where they provide a first line of defence by rapidly producing IgM and class-switched IgG antibodies in response to infections by blood-borne viruses and encapsulated bacteria.
What causes marginal zone lymphoma?
The causes of nodal marginal zone lymphoma (NMZL) are mostly unknown. It is sometimes linked to long-term infection with the hepatitis C virus (HCV). But it is important to remember that most people with HCV will not develop lymphoma. NMZL can affect people of all ages but is most common in people over the age of 50.
What does marginal zone mean?
Marginal zone lymphomas are types of slow-growing (low-grade) non-Hodgkin lymphomas that develop from B cells. They are called marginal zone lymphomas because they develop in a particular region found at the edge of normal lymphoid tissues (collections of lymphocytes) called the marginal zone.
What happens in the germinal center of a lymph node?
Germinal centers (GC) are sites in peripheral lymphoid tissues where B cells proliferate, switch classes of antigen receptors, and increase their affinity to antigens.
What type of lymphocyte is in the germinal center of a lymphoid follicle and why are they lighter in color?
The lighter staining areas are germinal centres, where the B-cells proliferate into antibody secreting plasma cells (see B-and T-lymphocytes).
What is a marginal zone?
The marginal zone is where the distribution of blood flow between slow and fast transit pathways is controlled. The slow pathways permit prolonged exposure of blood cells and particles to phagocytic cells.
Is marginal zone lymphoma the same as non Hodgkin’s lymphoma?
Is marginal zone lymphoma fatal?
Nonetheless, patients typically live for many years, requiring intermittent therapy when the disease becomes symptomatic. The reported 5 year overall survival (OS) of patients with MALT lymphoma is around 80%.