What is the pathophysiology of degenerative joint disease?

PATHOPHYSIOLOGY OF DEGENERATIVE JOINT DISEASES: Osteoarthrosis is characterized by progressive erosion of articular cartilage and bone overgrowth at the joint margins. Cartilage integrity requires balance between synthesis and degradation of matrix components.

What causes systemic osteoarthritis?

Osteoarthritis is a joint inflammation that results from cartilage degeneration. Degenerative joint disease is another name for osteoarthritis. Osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.

What is the underlying pathology of osteoarthritis?

The pathogenesis of OA involves a degradation of cartilage and remodelling of bone due to an active response of chondrocytes in the articular cartilage and the inflammatory cells in the surrounding tissues.

What causes moderate osteoarthritis?

What causes osteoarthritis? Primary osteoarthritis is caused by the breakdown of cartilage, a rubbery material that eases the friction in your joints. It can happen in any joint but usually affects your fingers, thumbs, spine, hips, knees, or big toes. Osteoarthritis is more common in older people.

What does degenerative etiology mean?

Degeneration refers to the process by which tissue deteriorates and loses its functional ability due to traumatic injury, aging and wear and tear.

What is systemic arthritis?

Systemic JIA (also called Still’s disease) is the most serious, but least common form of the disease. It affects one or more joints and causes inflammation of internal organs, including the heart, liver, spleen, and lymph nodes.

What is bilateral osteoarthritis?

Bilateral knee arthritis occurs when both knees are affected with OA. OA is a painful, degenerative condition that can reduce your mobility and make daily tasks difficult to manage. Early diagnosis and treatment may decrease joint damage and improve your overall quality of life.

Which joints are affected by osteoarthritis What in the physiology is affected?

Osteoarthritis can degrade cartilage, change bone shape and cause inflammation, resulting in pain, stiffness and loss of mobility. OA can affect any joint, but typically affects hands, knees, hips, lower back and neck.

What is the pathophysiology of joint pain?

Irrespective of the underlying mechanisms, joint pain usually originates in activation of nociceptors, or free nerve endings. Nociceptive signals release a large number of neuromediators, such as substance P and the calcitonin gene-related peptide.

What is moderate osteoarthritis?

Moderate osteoarthritis, or grade 3 OA, is when your cartilage breaks down even further, causing increased joint pain and stiffness. Pain and stiffness, especially in the hips and knees, are noticeable after resting, such as from sitting for a long time.

What causes early osteoarthritis?

Research shows a joint injury suffered at any age increases the risk of early onset osteoarthritis. In the knee, for example, sports injuries — such anterior cruciate ligament (ACL) and meniscus (cartilage) tears — are associated with rapid or early onset post-traumatic arthritis, a form of osteoarthritis.

What is the pathophysiology of osteoarthritis in India?

The pathophysiology of osteoarthritis. Abstract. Osteoarthritis is a chronic, inflammatory joint disease in the world. In India more than 20% of total population is suffering from arthritis, although the main cause of disease is unknown, morphological changes observed in OA include cartilage erosion as well as inflammation.

What is the role of ECM in pathophysiology of osteoarthritis?

It is a complex disease whose pathogenesis, changes the tissue homeostasis of articular cartilage and subchondral bone, determine the predominance of destructive processes. A key role in the pathophysiology of articular cartilage is played by cell/extra-cellular matrix (ECM) interactions.

What are the biochemical factors that trigger osteoarthritis?

Complex network of risk factors and biochemical parameters, including cytokines, proteolytic enzymes trigger the disease, by knowing the exact mechanism of progressive of disease, it may help in finding the new drug for reducing pain and curing of the joint disease.

What is the diagnosis and treatment of osteoarthritis?

Osteoarthritis: Pathology, Diagnosis, and Treatment Options Osteoarthritis (OA) is a worldwide endemic and debilitating disease. Previously thought to simply be damaged from “wear and tear,” OA is now understood to be a complex interaction of local and systemic factors.