What is the structure of Colace?

Docusate sodium

How is Sulfosuccinate made?

Manufacture: Sulfosuccinate is produced by reacting coconut-oil derived ethoxylated lauryl alcohol with sulfosuccinic acid which is made from maleic anhydride followed by addition of sodium bisulfite.

What is dialkyl sodium sulfosuccinate?

The dialkyl sulfosuccinate salts primarily function as surfactants in cosmetics. The Panel reviewed the new and existing available animal and clinical data in making its determination of safety.

What is docusate sodium made of?

Docusate Sodium is the sodium salt of docusate, a dioctyl salt and an emollient laxative with stool-softening activity. Docusate decreases surface tension and emulsification of fecal matter and allows water to penetrate and mix with stool. As a result, it softens the stool. Sodium docusate is an organic sodium salt.

How is Colace metabolized?

Docusate is metabolized by the liver and undergoes extensive first-pass metabolism to both active and inactive metabolites. Despite its hepatic metabolism and high level of plasma protein binding, it has not been implicated in causing drug-drug interactions.

What is the prototype of docusate?

The dosage for docusate sodium [Colace], the prototype surfactant, is shown in Table 63.4. Administration should be accompanied by a full glass of water.

Is Sulfosuccinate a sulfate?

Disodium Lauryl Sulfosuccinate is a sulfate-free anionic surfactant and ECOCERT approved. It is an excellent Foaming agent which produces a creamy rich lather in your products.

Is Sulfoacetate a sulfate?

Sodium Lauryl Sulfoacetate (SLSA) has a very similar name to one of the most common sulfate ingredients, Sodium Lauryl Sulfate (SLS), so you may be tempted to avoid it. Both ingredients are surfactants that can create bubbles and lather in cleansers, but that is pretty much where the similarity ends.

What is dioctyl sodium?

Dioctyl sodium sulfosuccinate (DSS) is an anionic surfactant substance that traditionally has been recommended as a laxative and stool softener for a variety of vertebrates ranging from humans to rodents.

What is DSS enema?

DSS Surfactant Indications Water miscible solution of Dioctyl Sodium Sulfosuccinate 5%. To be used as an aid in the relief of constipation and impactions caused by hard fecal masses in horses, dogs and cats.

How is docusate sodium metabolized?

Does Colace affect the liver?

There have been no cases of clinically apparent liver injury attributable to docusate published in the literature and, thus, significant liver injury from docusate must be exceedingly rare, if it occurs at all.

What is the structure of sodium sulfosuccinate esters?

Structure of sodium sulfosuccinate esters. Sodium sulfosuccinate esters are organic compounds with the formula NaO 3 SCH (CO 2 R’)CH 2 CO 2 R where R and R’ can be H or alkyl groups. They comprise a large class of surfactants and emulsifiers used in cosmetics, pharmaceuticals, and cleaning agents. They are colorless salts.

What kind of surfactant is dioctyl sodium sulfosuccinate?

Dioctyl Sodium Sulfosuccinate. Bis(2-ethylhexyl)sulfosuccinate (AOT) is a surfactant with an anionic head group and has historically been the most commonly studied RM surfactant system.

What does docusate sodium sulfosuccinate stand for?

Docusate is the common chemical and pharmaceutical name of the anion bis (2-ethylhexyl) sulfosuccinate, also commonly called dioctyl sulfosuccinate ( DOSS ). Docusate sodium is on the World Health Organization’s List of Essential Medicines.

How much does dihexyl sodium sulfosuccinate weigh?

Dihexyl sodium sulfosuccinate PubChem CID 516989 Molecular Weight 388.5 Parent Compound CID 82160 (Dihexyl sulfosuccinate) Component Compounds CID 82160 (Dihexyl sulfosuccinate) CID 5 Date s Modify 2021-09-05 Create 2005-03-27