What is the toxic level for Depakote?

The therapeutic range for valproic acid is 50-100 mcg/mL. The toxic level is >100 mcg/mL.

Can you overdose from Depakote?

An overdose of Depakote could be fatal, so seek immediate help or call the Poison Help Line at 1-800-222-1222 if you overdose. Overdose symptoms can include irregular heartbeat, sleepiness, and loss of consciousness resulting in a coma.

What are the signs of Depakote toxicity?

CNS findings in cases of VPA overdose may include the following:

  • Coma.
  • Confusion.
  • Somnolence.
  • Worsened seizure control.
  • Dizziness.
  • Hallucinations.
  • Irritability.
  • Headache.

How do you treat Depakote toxicity?

Treatment / Management Therapy for patients with valproate toxicity is mainly supportive and includes initial stabilization and resuscitation. Measures include maintenance of airway, breathing, and circulation. Establish early IV access as intravenous fluid administration for the patients presenting with hypotension.

When do you draw Depakote levels?

It is recommended that trough levels for the DR version be drawn immediately prior to the morning dose, assuming a twice-daily dosing strategy. For once-daily divalproex ER regimens, the ideal time to draw serum levels is immediately prior to the next scheduled dose.

Is 2000 mg of Depakote too much?

The mean daily dose usually ranges between 1000 – 2000 mg valproate. Patients receiving daily doses higher than 45 mg/kg/day body weight should be carefully monitored. Continuation of treatment of manic episodes in bipolar disorder should be adapted individually using the lowest effective dose.

What are the side effects of too much Depakote?

Diarrhea, dizziness, drowsiness, hair loss, blurred/double vision, change in menstrual periods, ringing in the ears, shakiness (tremor), unsteadiness, weight changes may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

How much is too much divalproex?

The maximum recommended dosage is 60 mg/kg/day. The recommended starting dose of divalproex for the prevention of migraine is 250 mg twice daily. The dose may be increased until migraine control is achieved. The maximum recommended dose is 1000 mg/day as needed.

Can you overdose on olanzapine?

The most common symptoms that arise as a result of olanzapine overdose include central nervous system (CNS) depression with somnolence, blurred vision, low blood pressure, respiratory depression, extrapyramidal and anticholinergic effects, as well as exceptionally high fever.

What is peak drug level?

The peak level is the highest concentration of a drug in the patient’s bloodstream.

What is a normal carbamazepine level?

The therapeutic range for carbamazepine when it is taken by itself is about 4 to 12 mcg/mL (micrograms per milliliter). Levels above 15 mcg/mL are considered toxic.