NSI-189 is a novel, neurogenic compound independent of serotonin or norepinephrine reuptake inhibition pathways. The compound was discovered by systematic screening of a chemical library against in vitro model of HI neurogenesis using a stable cell line of human fetal HI neural stem cells (US Pat.
Is NSI-189 safe?
Conclusions: These results suggest that NSI-189 is effective as a safe adjunctive therapy, with most compelling antidepressant and procognitive benefits noted in patients with moderate depression.
How long does NSI-189 last?
Across all three doses, NSI-189 was well-tolerated with no serious adverse events. The mean half-life of the drug was 17.4 to 20.5 hours, with steady-state reached after 96 to 120 hours.
Is anhedonia a symptom of major depressive disorder?
People who experience anhedonia have lost interest in activities they used to enjoy and have a decreased ability to feel pleasure. It’s a core symptom of major depressive disorder, but it can also be a symptom of other mental health disorders.
How does adrafinil work?
The principal pharmacological effect of amphetamines is to increase the release and decrease the reuptake of the neurotransmitters dopamine and norepinephrine throughout the brain. The stimulants adrafinil and modafinil are agonists at the noradrenergic postsynaptic (α1) receptors.
What is Selank used for?
Selank by itself has traditionally been prescribed for anxiety and depression. Selank has pronounced anxiolytic activity and acts as a stable neuropsychotropic, antidepressant, and anti-stress medication. Semax is used as a therapeutic for patients with pathologies related to brain circulation dysfunction.
What is the best treatment for anhedonia?
A combination of therapy and psychoactive drugs is usually the most effective treatment for both anhedonia and depression. Medications that alter the way the brain processes rewards are especially helpful with anhedonia. Some people also experience an improvement with lifestyle changes.
Does Selank make you sleepy?
It has nootropic/anxiolytic effects- this means it calms you mentally. It works well when used in combination with anti-depressant medications or all by itself. It decreases inflammation in the brain. It encourages deep restful sleep.
What kind of drug is NSI-189 used for?
” NSI-189 is an experimental drug being studied by Neuralstem, Inc.  Research into NSI-189 has been funded by the Defense Advanced Research Projects Agency (DARPA) and the National Institutes of Health (NIH) for the treatment of major depressive disorder .”
Where does NSI-189 pass the blood-brain barrier?
NSI-189 is a benzylpiperizine-aminiopyridine. R It may pass the blood-brain barrier. R In humans in vitro as well as rodents in vivo, NSI-189 stimulates neurogenesis in hippocampal slices (specifically profound in the dentate gyrus).
What does anhedonia stand for in medical terms?
Originating from the Greek ἀv- an-, “without” and hēdonē, “pleasure”, anhedonia is the inability to feel pleasure, the inability feel anything good. Sufferers who don’t know the word will usually describe it as a zombie-like state, feeling like a robot, feeling numb, feeling disconnected, or what-have-you.
What kind of SSRI do you take for anhedonia?
My anhedonia was SSRI induced, either by Zoloft or Fluoxetine. My baseline Symptoms when unmedicated are – (10 being max, 1 being lowest impact) My journey to treating Anhedonia came from Forums, befriending people who are experts in pharmacology, and from other people’s experiences.